Immunotherapy相关论文
The Rational Combination Strategy of Immunomodulatory Latency Reversing Agents and Novel Immunothera
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Graves病(GD)传统治疗方案虽然有一定疗效，但仍然有必要探究新型疗法。针对GD发病机制，通过消耗B淋巴细胞和作用于促甲状腺素受体(TS......
ASCO-GU是泌尿生殖肿瘤诊疗领域的标志性会议。2022 ASCO-GU会议上公布了帕博丽珠单抗辅助治疗延长随访与阿昔替尼/阿维鲁单抗联合......
Newcastle Disease Virus/HK84: Next Potential Star for Targeted Immunotherapy of Hepatocellular Carci
Of all liver cancers, hepatocellular carcinoma (HCC) is report-ed as the most common globally, with the highest incidenc......
肠道是营养成分消化吸收的主要场所，肠道菌群参与了机体的能量存储、代谢、免疫等活动，在维持机体健康及诱导肿瘤发生等方面具有重要......
三阴性乳腺癌(triple negative breast cancer，TNBC)是乳腺癌中预后最差的类型，严重威胁女性生命健康。化疗和免疫治疗是TNBC最常用......
Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide long-te......
Chronic inflammation promotes tumor development,progression,and metastatic dissemination and causes treatment resistance......
The immune checkpoints,cytotoxic T-lymphocyte-associated antigen 4(CTLA-4)and pro-grammed cell death protein-1/ligand-1(......
c-Met-targeted chimeric antigen receptor T cells inhibit hepatocellular carcinoma cells in vitro and
c-Met is a hepatocyte growth factor receptor overexpressed in many tumors such as hepatocellular carcinoma(HCC).Therefor......
The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role ......
我国是肝癌大国，近年来肝癌治疗方式越来越趋于综合性的治疗，主要包括手术、消融、介入栓塞、放疗、化疗、靶向、免疫、肝移植等治疗......
目的:通过总结分析国内多中心、真实世界的大样本数据，为联合免疫治疗的新辅助治疗对结直肠癌患者的临床应用提供借鉴和依据。方法:......
新辅助治疗在直肠癌、局部进展期结肠癌和可切除的转移性复发性结直肠癌中应用广泛。错配修复缺陷（dMMR）和微卫星高度不稳定（MSI-H）结......
微卫星高度不稳定（MSI-H）结直肠癌约占所有结直肠癌患者的10%~15%，而晚期患者中MSI-H人群仅占5%。既往研究显示，早中期MSI-H结直肠癌预......
免疫治疗已成为微卫星高度不稳定（MSI-H）或错配修复缺陷（dMMR）结直肠癌的重要治疗方案，从晚期疾病的后线治疗到一线治疗，甚至在早期结直......
Interleukins (ILs) and associated cytokines serve as the means of communication for immune cells and non-immune cells. T......
DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-t
The amyloid-β (Aβ) oligomer, rather than the Aβ monomer, is considered to be the primary initiator of Alzheimer\'s ......
Diverse and precision therapies open new horizons for patients with advanced pancreatic ductal adeno
Pancreatic ductal adenocarcinoma (PDAC) is a common cause of cancer-related death, and most patients are with advanced d......
The gastrointestinal tract is an eight-meter-long pathway that includes various organs,which runs from the mouth to the ......
There is growing recognition that neutrophils play an important role in cancer initiation,progression and metastasis.Alt......
ERK pathway regulated the programmed death ligand-1 (PD-L1) expression which was linked to the response of programmed de......
Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunothera
Genomic instability remains an enabling feature of cancer and promotes malignant transfor-mation.Alterations of DNA dama......
Ferroptosis,an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsatu-rated-fatty-acid......
Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicin
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare adverse cutaneous reaction with a low incidence ......
目的:分析特瑞普利单抗联合阿昔替尼治疗晚期肾细胞癌的初步疗效与安全性。方法:回顾性收集北京大学肿瘤医院接受特瑞普利单抗联合......
小细胞肺癌（small cell lung cancer，SCLC）约占所有肺癌的15%，是一种高度侵袭性神经内分泌肿瘤，吸烟为主要高危致病因素，其生长迅速、转......
Development and validation of a tumor microenvironment-related prognostic signature in lung adenocar
Objective Tumor-infiltrating immune cells and stromal cells in the tumor microenvironment (TME) significantly affect the......
Alzheimer\'s disease is a neurodegenerative disease that accounts for most of the 50-million dementia cases worldwide ......
免疫检查点抑制剂（ICIs）的临床应用显著改善肝细胞癌（简称肝癌）病人预后。随着ICIs在肝癌中的广泛应用，免疫相关不良反应（irAE）越来越受到......
Background: Treatment of hepatocellular carcinoma (HCC) is challenging as most patients are diagnosed at advanced stage ......
Background::The scale assessment was helpful in predicting the presence of antibodies to autoimmune encephalitis. This s......
Immunotherapy is a rapidly developing area of cancer treatment due to its higher specificity and potential for greater e......
Cancer stem cells(CSCs)with their self-renewal ability are accepted as cells which initiate tumors.CSCs are regarded as ......
Many patients with cancers have low levels of CD4+ in their peripheral blood.However,the molec-ular mechanism is still u......
Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and target
Locoregional therapies (LRTs) of hepatocellular carcinoma (HCC) represented by ablation and TACE has become the main mea......
Peripheral CD4+T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chin
Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifyi......
Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involve......
Single-cell Analysis Technologies for Immuno-oncology Research:from Mechanistic Delineation to Bioma
The successes with immune checkpoint blockade (ICB) and chimeric antigen receptor(CAR)-T-cell therapy in treating multip......
目的 观察信迪利单抗联合含铂双药化疗一线治疗晚期非小细胞肺癌的疗效及安全性。方法43例晚期非小细胞肺癌患者，一线采用信迪利单......
Alzheimer\'s disease (AD),the most common type of dementia,is becoming a major challenge for global health and social ......
Potential synergistic implications for stromal-targeted radiopharmaceuticals in bone-metastatic pros
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Despite impressive survival benefits with immunotherapy in patients with various solid tumors,the full potential of thes......
Immunotherapy and therapeutic vaccines in prostate cancer:an update on current strategies and clinic
In recent years, immunotherapy has emerged as a viable and attractive strategy for the treatment of prostate cancer. Whi......
NanoAu-Cocktail Activated Dendritic Cells Increases Accumulation in Liver-Draining Lymph Nodes and E
The lack of efficient antigens and activators delivery systems[1],as well as the restricted migration of dendritic cells......
Regular sleep and cytotoxic nanomedicine targeting tumor-associated macrophages for synergistic immu
Lifestyle is one of the main influencing factors on the initiation and progression of malignancies.Tumor-associated macr......
Reversal of Immune-Suppressive Tumour Microenvironment and Induction of Tumouricidal Cascade by Sele
Cancer related death has accounted secondly to the total death.Unfortunately,traditional methods(e.g.radiotherapy or che......
Laser-induced thermal therapy referred to as photothermal therapy employs laser light energy sources and provides a prec......
Modulation of macrophage behavior with glucomannan polymers for cancer immunotherapy and bone regene
Emerging evidence suggests that macrophages play diverse but essential roles in a variety of physiological and pathologi......
